Hipothalamo-pituitary axis-the ovaries are mutually affects between hipothalamus, pituitaria, and ovaries. In hipothalamus there are 2 central regulator of the reproductive cycle cyclic and tonic center that serves as a regulator mechanism GnRH secretion.

Tonic center of ventromedial nucleus and arkuatus nucleus, consisting of cyclic central area preoptik supra kiasmatik. In the cyclic female dominant center so that there is a period repeated. The relationship between the anterior hipothalamus with hipofise the vasa porta and no feedback.

Hormones are chemical substances produced by endocrine glands
which has a certain effect on the activities of other organs in the body. Sex hormones are substances released by sex glands and adrenal glands directly into the stream blood. They are partly responsible for the
determine the sex of the fetus and for the development of organs
normal sex. They also started puberty and then play a role in regulating sexual behavior.

Sex hormones can be grouped into major estrogen or androgens. Both classes have hormones in men and women, but in different levels. Most men produce 6-8 mg of testosterone (an androgen) per day, compared
with most women who produce 0.5 mg per day.

Estrogen also exist in both sexes, but in the number of
greater in women. Estrogen Sex hormone estrogen is produced mainly by
ovaries that stimulates the growth of child sex organs women, such as: breast and genital hair, known as secondary sex characteristics. Estrogen also regulates the cycle menstruation. In most women, ovarian hormones are not
play an important role in their sex drive. Deep a study in women under the age of 40 years, 90% reported no change in sexual desire or function
after sex hormone derived for the second appointment uterus. A regulator of estrogen function intraovarium stimulate follicular growth.

In collaboration with FSH and LH stimulates the formation of the LH receptor (positive feedback), cause regression of the corpus luteum and a decrease in levels progesterone. Estrogen is important in maintaining the condition of the surround vagina and elasticity, as well as in producing liquid lubricate the vagina. They also help to keep the texture and function of female breasts.

Progesterone
Prolactin (PRL) is also called lactogenic hormone (LTH). Prolactin
play an important role to maintain the corpus luteum, the initiation of cell luteinisasi granulosa, maintain progesterone synthesis by luteal cells,
Mom glands stimulate growth. Prolactin increases the number of LH receptors and progesterone production, in cooperation with LH. PRL suppress (inhibit) the production of estrogen by inhibit aromatase activity by FSH and LH in the SG induces the production of androgens. PRL contribute to inhibits progesterone and estrogen.

Follicle stimulating hormone (FSH)
FSH is secreted by the anterior and has pituitaria receptor
specific to the ovarian follicle granulosa cells and testicular Sertoli cells.
FSH is a glycoprotein hormone. FSH is a hormone a dominant role in stimulating:
1. Growth and development of ovarian follicles.
2. Stimulate the production of estrogen.
3. Stimulates spermatogenesis.

Luteinizing Hormone (LH)
LH plays an important role for;
1. Final growth of follicles.
2. The process of ovulation.
3. Changes in the granulosa cells become the corpus luteum.
4. Stimulates secretion of progesterone.
5. Stimulate androgen production.